Lab to Present 16 Abstracts at the Annual Society for NeuroOncology Meeting

Our lab members and collaborators are presenting 14 abstracts at the Annual Society for NeuroOncology Meeting (click on title for abstract):

Lab Open House During The Annual Society for NeuroOncology Meeting

Come join us for snacks and drinks at a reception to hear about the Comprehensive NeuroOncology Program at Mayo Clinic in Phoenix including:
• Scientific Updates from Mayo Faculty – including a poster session
• Tour of the Cancer Center and Proton Beam
• Hosted in the Precision Neurotherapeutics Lab.
 
Bus pick up at the SNO conference venue JW Marriott Desert Ridge at 5:15pm.

Our latest paper exploring the role of differential blood-brain barrier permeability and therapeutic sensitivity in glioblastoma treatment response is up on bioRxiv

When a drug fails, often a mismatch between drug and target is blamed, and in brain tumors, there is also a possibility of insufficient amounts of drug being delivered to all of the brain tumor. In dense tumor regions, there is a break down of the blood-brain barrier due to tumor angiogenesis, which may allow drugs to enter the tumor. However, this does not occur in the outer regions of tumor where smaller numbers of tumor cells invade and spread outward, potentially leaving a large portion of tumor undertreated. To explore these dynamics, MNO lab postdoc Susan Massey and recent ASU graduate Javi Urcuyo developed an ordinary differential equation model based on experimental data from our Mayo Clinic colleague Jann Sarkaria’s Translational Neuro-Oncology lab. Our model shows how overall exposure to treatment may be more influential than therapeutic resistance in determining the therapeutic outcome.

S. C. Massey, J. C. Urcuyo, B. M. Marin, J. N. Sarkaria, K. R. Swanson. Quantifying glioblastoma drug response dynamics incorporating resistance and blood brain barrier penetrance from experimental data. Bulletin of Mathematical Biology, in review. BioRxiv doi: 10.1101/822585

2018 Newsletter

This year we have put together a year end summary/newsletter to keep you apprised of our ongoing efforts and new endeavors

 

MNO Lab Presents 7 Posters at Mayo Clinic Young Investigators Research Symposium

In March of 2018, seven MNO lab members presented posters at the Mayo Clinic Young Investigators Research Symposium in Rochester, MN. The group included Aditya Khurana (Mayo Medical School student), Cassandra Rickertsen (Image Analysis Team Lead), Gustavo De Leon (post-baccalaureate), Susan Massey (post-doctoral researcher), Sara Yee (ASU undergraduate), Julia Lorence (ASU undergraduate), and Paula Whitmire (post-baccalaureate). Gustavo De Leon was selected to give a poster teaser presentation of his research on identifying early indicators of immunotherapeutic response in GBM patients. The event served as an excellent opportunity for our young investigators to present their research and network with investigators from the other Mayo Clinic campuses.