The Mathematical Neuro-Oncology Research Lab Presents
David R. Grimes, PH.D.
Post-Doctoral Research Associate
CR UK/MRC Oxford Institute for Radiation Oncology
Gray Labs, Radiation Research Institute
University of Oxford
Modeling the role of oxygen in the tumor micro-environment
MONDAY, MARCH 2ND, 2015
2:00 PM–3:00 PM
676 N. SAINT CLAIR ST. SUITE 1300
MATHEMATICAL NEURO-ONCOLOGY LAB
In tumours, hypoxia is associated with poor prognosis, increased likelihood of metastasis and a marked resistance to radiotherapy. While imaging techniques, such as PET with hypoxia tracers can indicate hypoxic sub-volumes inside a tumour, these modalities are limited by the physics of the system to a resolution in the millimetre regime, whereas tumour oxygen levels can vary over a micron scale. Mathematical models of cellular oxygen distribution are of paramount importance to bridge this scale gap and aid interpretation of clinical image data, and ultimately treatment prescription. This talk discusses some approaches to -and challenges of -the oxygen micro-environment and its significance to treatment.